That statement make me think again the inevitable truth about human's nature that God himself create human with hunger for Him. If we look back in a history of human kind, ancient humans have some kind of sense of admiration or fear to thunder, big mountain, rock, tree, and so on. They worshiped it all. I think that is an evindence of our longing to God himself. Somewhere in our heart, we believe that there is a great power beyond us as a human that control all the universe. But as all human have sinned, we will never able to know Him correctly except He reveal himself to us. The imperfect will never reach the perfect one. It is only God who has the initiative to reach human, not the opposite.
In my humble opinion, i think the very basic of our hunger, is our hunger for love. We want to love and be loved simply because it will make us feel happy and joyful. Love is the basic human need. In love there is respect, charity, goodness, and meekness. Is not that what we are looking for in life? Christian faith said that God is Love. And it also means that we should need God. For God is love itself.
But, how if human choose to deny the existence of God?
Again, i think, it is not possible. If we deny God's existence, somebody/something must take His place, for we are created with hunger for Him. We must make gods for ourself if we chose to deny God.
Malcom Muggridge once said briliantly :
“If God is dead, somebody is going to have to take his place. It will be megalomania or erotomania, the drive for power or the drive for pleasure, the clenched fist or the phallus, Hitler or Hugh Hefner.”So please do not seek pleasure beyond God himself for there is no such thing ever existed. I belive, if we try to seek happines/joyful/pleasure beyond God, we will end up in regret. Human is created to be "enslaved" to God. Because He himself who created us. We will always hungry for Him. Of course for our own good. That is what i belive.